Lab Reactor – a modular flow reactor
Poster Sep 21, 2017
Clemens R. HORN, Olivier LOBET, Mohammed Acherki, Bertrand Gallet
The flow chemistry and microreactor technologies have proven to be an innovative tool to achieve new chemical path synthesis, improving safety and increasing yield and, conversion . The possibility to scale-up the reactions for the industrial production increases the need to screen synthesis in a robust way . Corning has developed a versatile and easy to use microreactor for the laboratory, the Lab Reactor, keeping in mind the possibility to scale-up the process.
The glass reactor allows an easy follow-up due to its transparent structure. Emulsion, opacity and colours changes are easy to observe and give important information on the reaction mechanism and kinetics . A Wittig reaction has been carried out in the LabFlow reactor to evaluate the influence of the residence time, the temperature and the flow rate.
In addition to provide an extremely resistant structure toward pressure, corrosion and temperature difference, the glass Lab reactor is suitable for the photochemistry. The modular LED panels offer an almost monochromatic light for numerous wavelengths, increasing conversion and selectivity . The synthesis of cis-Stilbenes occurs through photo-isomerisation of trans-stilbene . The tight control of the wavelength and residence time provided by the Photo Lab Reactor helps to determine the optimal reaction conditions for most of the photoreactions.
Knockout of microRNAs Using the CRISPR-Cas9 System with Paired Synthetic crRNAsPoster
We utilized paired synthetic crRNAs coupled with our synthetic tracrRNA in cells transduced with lentiviral Cas9 to perform a functional knockout on hsa-miR-221. This three-part system (crRNA, tracrRNA and Cas9) has demonstrated efficient gene editing when used with only one guide RNA, but the goal was to use two crRNAs to remove the entire stem-loop.READ MORE
New Biotransformation Prediction Engine Integrated into a Metabolite Identification SolutionPoster
Here we present a new prediction algorithm that determines the likelihood of biotransformation reactions, and subsequent metabolite identification, within an automated processing routine.READ MORE
A New Method for Analyzing MSe/All Ions Fragmentation in Xenobiotic Metabolism StudiesPoster
During early drug discovery, the study of metabolism plays an essential role in determining which drug candidates move forward into development and later stages. As an alternative to traditional Data Dependent Acquisition (DDA), the use of MSE/All Ions Fragmentation (AIF) has become common in metabolite identification workflows for the analysis of metabolic hot spots. Here we present a solution for analysis of MSE/AlF in metID studies.READ MORE
5th edition of the International Conference Clinical Oncology and Molecular Diagnostics
Jun 17 - Jun 18, 2019