Mechanistic Prediction of Volume of Distribution: The Influence of Plasma and Tissue Binding
Poster Dec 07, 2010
Kiril Lanevskij, Remigijus Didziapetris, Pranas Japertas
Drug molecules circulate in plasma either free or bound to plasma proteins such as albumin (acidic drugs), α1-acid glycoprotein (basic drugs), lipoproteins (neutral compounds), etc. The extent of plasma protein binding (PPB) is a key determinant of all subsequent distribution processes including CNS permeation, partitioning into tissues, and elimination.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysisPoster
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.