"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
Poster Apr 01, 2011
David Obermayer, Bernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Markus Damm and C. Oliver Kappe
According to the Arrhenius law a further increase of reaction temperatures (e.g. moving from 150 to 250°C) using a suitable reactor environment (e.g. stainless steel) leads to even shorter reaction times.
Working in a high-temperature/high-pressure continuous flow regime, many reactions requiring unusually harsh, exotic or extremely dangerous reaction conditions or the use of supercritical solvents are easily accessed and safely controlled in the microreactor environment.
A recent example of a two-step synthesis in stainless steel equipment is the synthesis of the pesticide Boscalid (BASF) in a Suzuki-Miyaura cross coupling - hydrogenation sequence.