Synthesis of 4,5-dihydroisoxazoles from N-nitroso-4,5 dihydropyrazoles under Microwave Irradiation
Poster Oct 27, 2006
Kostikov R.R., Stepakov A.V., Galkin I.A and Molchanov A.P.
4,5-Dihydroisoxazoles have been used as key intermediates in the synthesis of a bioactive molecules and are found in pharmaceutical agents such as glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors and human leukocyte elastase inhibitors. In the present work 4,5-dihydroisoxazoles have been prepared by thermal removal of nitrogen from N-nitroso-4,5-dihydropyrazoles under microwave irradiation.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysisPoster
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.