A Fragment Screening Library for X-ray Crystallography
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The library contains a diverse set 352 small molecule compounds with mean molecular weight of 155 Da. The chemical compound types (typically, simple decorated rings) are suitable for efficiently probing protein sites to determine binding substructures for lead discovery. The compounds in the library are pre-plated so as to provide 100uL of each compound at 200mM concentration. All compounds have been tested to ensure adequate solubility in DMSO.
To assist in the experimental design and interpretation of fragment screening experiments using mixtures the compounds are arranged in shape-diverse groups and 3D structure models of all compounds are provided.
For additional information on Zenobia Therapeutics, Inc., contact Dr. Vicki Nienaber at vicki@zenobiatherapeutics.com or visit www.zenobiatherapeutics.com. For additional information on Zenobia's fragment library, contact Leslie Hernandez at leslie@zenobiatherapeutics.com.
Leslie Hernandez, Director of Sales, Zenobia Therapeutics, Inc.
