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CellCiphr(TM) Toxicity Panels Revalidated by Cyprotex
Product News

CellCiphr(TM) Toxicity Panels Revalidated by Cyprotex

CellCiphr(TM) Toxicity Panels Revalidated by Cyprotex
Product News

CellCiphr(TM) Toxicity Panels Revalidated by Cyprotex


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Confirming the success of the cross validation, this client has resumed using CellCiphr(TM) to identify potential toxicities in its pipeline of drug candidates. In addition, three other clients have also resumed using CellCiphr(TM). These include two major pharmaceutical companies and the US Environmental Protection Agency (EPA), where CellCiphr(TM) has been selected for Phase II participation in the ToxCast(TM) programme. In addition, a fifth, new client has completed its first CellCiphr(TM) study.

The CellCiphr(TM) technology Cyprotex acquired from Cellumen applies High Content Screening (HCS) technology to cellular models of disease and toxicity. The technology uses a proprietary advanced informatics and data interpretation platform to assess cytotoxicity to improve prediction of in vivo toxicity. The CellCiphr(TM) technology is an extensively validated approach that was co-developed with the participation of eight external pharmaceutical and government partners. The CellCiphr(TM) toxicity profiling panels can reliably identify toxic compounds before entering further preclinical testing.

Drug development failures due to toxicity are a major financial burden to the pharmaceutical industry. These failures are increasingly occurring both in costly late-stage development and, worse, after commercialisation. Identifying potential toxic liabilities at an early stage significantly reduces both the cost of drug development and the need for animal testing.

Commenting on the CellCiphr(TM) technology, Dr Katya Tsaioun, Cyprotex's Chief Scientific Officer, said: 'Cyprotex's CellCiphr(TM) technology has been validated by major pharmaceutical companies and selected for use in the EPA's ToxCast(TM), programme as one of the core technologies in the National Toxicology Program. Our re-validation of this technology is a major milestone in Cyprotex's entry into the in vitro toxicology market that began in August with the acquisition of Apredica in the US, followed by the opening of our new UK toxicology laboratory'.

Dr. Tony Baxter, Cyprotex's Chief Executive Officer, commented: 'Approximately 25% of all spending on drug development is spent on the clinical trials of drugs that fail in those trials due to toxicity. This cost is now the largest source of economic inefficiency in drug development. Looking back, in 1995, 40% of clinical trial failures were due to ADME. But since the adoption of preclinical in vitro ADME, that figure is now below 10%. Cyprotex is at the forefront of applying in vitro technologies to the drug safety problem. Just as Cyprotex's in silico and in vitro ADME services were at the forefront of reducing inefficiencies due to ADME, the Company is now at the forefront of applying the same technologies to the growing problem of toxicity'.
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