We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Embedded Chondroitinase ABC Shows Promise for Spinal Injury Treatment
Product News

Embedded Chondroitinase ABC Shows Promise for Spinal Injury Treatment

Embedded Chondroitinase ABC Shows Promise for Spinal Injury Treatment
Product News

Embedded Chondroitinase ABC Shows Promise for Spinal Injury Treatment

The pioneering new therapy used AMSBIO’s Chondroitinase ABC

Want a FREE PDF version of This Product News?

Complete the form below and we will email you a PDF version of "Embedded Chondroitinase ABC Shows Promise for Spinal Injury Treatment"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

AMSBIO, a leading global supplier of Chondroitinase ABC enzyme, reports on the recent publication by Hu et al.** of the therapeutic efficacy of microtube-embedded Chondroitinase ABC on a group of dogs with naturally occurring spinal injuries. Developing new therapies for human spinal cord injuries is a challenging task because the damage is heterogeneous in terms of spinal location and severity. Ideally a new therapy should work for survivors with acute injuries as well as for those with chronic injuries that happened less recently.

This work, by Nick Jeffery and co-workers, describes a successful canine clinical trial of a drug therapy for chronic spinal cord injury, which demonstrated an improvement in limb coordination during walking. The pioneering new therapy used AMSBIO’s Chondroitinase ABC, a bacterial enzyme that removes sugar sidechains from extracellular matrix molecules including chondroitin sulfate proteoglycans (CSPGs) which are found within the intact and injured nervous system and act as potent inhibitors of axonal growth.

CSPGs are involved in the inhibition of axon regeneration after various forms of damage to the Central Nervous System, including stroke or spinal cord injury. The enzyme Chondroitinase ABC purified from Proteus vulgaris, degrades these CSPGs, and has been shown to promote functional recovery and neural regeneration.

AMSBIO has developed a highly purified Chondroitinase ABC enzyme supplied as a protease-free, carrier-free format, with low-endotoxin levels for use in neuroscience and regenerative medicine research. The trial reported here buffered the enzyme in trehalose and embedded it in lipid microtubes to render it heat-stable and long-acting at mammalian body temperatures.

** Hilary Z Hu et al, Brain, Volume 141, Issue 4, 1 April 2018, Pages 1017–1027 (see https://doi.org/10.1093/brain/awy007)
Advertisement