Improving Accuracy, Productivity and Relevancy of Cell Based High Throughput Assays
Product News Dec 16, 2013
AMSBIO has announced the launch of a 384-well version of the popular Alvetex®Scaffold cell culture plates. The new Alvetex®Scaffold 3D cell culture plates provide biopharmaceutical companies with a new tool to improve the predictive accuracy, productivity and biological relevance of their cell based high throughput testing.
“We are excited about extending the application of 3D cell culture to high throughput laboratories and groups who need to test larger numbers of parameters with cells in a 3D environment. We have seen excellent uptake of the Alvetex®Scaffold 96 plates but customers have been asking for some time when we will help them do more with 3D cell culture” said Alex Sim, President of AMSBIO.
“Our customers have been delighted with the incredibly simple workflow and the ease of analysis when using Alvetex® 3D cell culture products” he added.
A typical application for this new product is in cancer cell cytotoxicity testing. The Alvetex®Scaffold 384-well plates allow scientists to grow tumour cells in a way that better mimics the way these cells grow in vivo.
It is then very simple to test the cytotoxic effect of novel or existing anti-cancer compounds using standard cell health assays such as MTT, XTT, extracellular oxygen consumption and many others.
Researchers can then easily retrieve RNA and protein from the drug treated cells to study mechanism of action and look for biomarkers. Alvetex®Scaffold plates work seamlessly with liquid handling robotic systems further enhancing the high throughput potential of users cell based testing.
Alvetex®Scaffold is also available through AMSBIO in other formats including a 12-well culture plate, 24-well culture plate, 96 well plate, 6-well and 12-well inserts. These formats enable scientists to construct different 3D cell culture models and assays.
These include screening of novel drugs / drug combinations on 3D culture and co-culture models, co-culture to study cell-cell or cell-matrix interactions, the growth of cells at the air-liquid interface and the long-term culture of cells.