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Malvern Launches Two New-generation Isothermal Titration Calorimeters

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Malvern Instruments has launched two new-generation isothermal titration calorimeters (ITC), advancing its recently acquired MicroCal range to further support life science researchers studying biomolecular interactions.

The new manual Malvern MicroCal PEAQ-ITC and fully automated Malvern MicroCal PEAQ-ITC Automated systems are designed to deliver the enhanced functionality and robust performance now demanded of this essential tool.

ITC allows the label-free study of a wide variety of molecular interactions and the Malvern MicroCal PEAQ-ITC and PEAQ-ITC Automated systems deliver exceptional sensitivity and outstanding data quality at high speed. Redesigned software ensures intuitive operation while automated data analysis means even non-experts can interpret with confidence. Options for walk-away automation offer quicker screening, faster hit validation and greater laboratory efficiency, and Malvern remains the only producer of a fully automated ITC system.

These new ITC systems are the product of more than 30 years of MicroCal experience and market leadership in microcalorimetry and build on long-established MicroCal ITC technology. As part of Malvern Instruments, the MicroCal product range is now supported around the world by Malvern’s extensive network of dedicated technical and application specialists, as well as via the company’s many helpdesks and through the provision of multiple online resources.

Malvern MicroCal PEAQ-ITC
Manual ITC systems are widely used in basic life science research, structure function analysis, protein research and drug target characterization. Incorporated in the new systems are user-friendly guided workflows with embedded help videos that give any level of user the ability to generate high quality data. In addition, high signal to noise gives confidence in data quality and in the relevance of the affinity and thermodynamic parameters generated. An all new data analysis software package can simulate experiment design, provide batch evaluation of large data sets and automated assessment of data quality, while its streamlined interface improves workflow by guiding the user to final figures and presentation quality graphs quickly and easily. In terms of hardware, a new automated washing system uses detergent to clean the sample cell and titration syringe, minimizing day-to-day maintenance and assisting the production of high quality reproducible data. Furthermore, this manual system is upgradeable to an automated ITC.

Malvern MicroCal PEAQ-ITC Automated
The Malvern MicroCal PEAQ-ITC Automated is a fully automated ITC system that will replace the current Malvern MicroCal Auto-ITC200. Its robust new design is coupled with the same all new data analysis package featured in the manual system. Such full automation has applications in many laboratories, but is ideally suited to industrial and other core facilities involved in small molecule drug discovery where large-scale target identification, hit validation and lead optimization are undertaken. By combining the best possible data quality and reproducibility with high speed, unattended operation, the Malvern MicroCal PEAQ-ITC Automated can provide early indications of high quality hits while freeing researchers for other tasks.