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MDS Introduces the CellKey™ System

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MDS Sciex has announced that it will unveil its CellKey™ System at the annual Society for Biomolecular Screening (SBS) Conference, September 11-15 in Geneva, Switzerland (Booth number 762).

The MDS Sciex CellKey™ System is designed to allow for the measurement of endogenous cell surface receptor activation in live cells and generates data that enables identification of the receptor coupling mechanism of unknown receptors (for example, orphan G protein-coupled receptors, GPCR’s).

The CellKey™ System is based on cellular dielectric spectroscopy (CDS) technology, an approach that removes the requirement for fluorescent or radio-labeled markers from the drug discovery workflow, thereby simplifying assay development.

MDS claims that, the sensitivity of CDS’ impedance-based measurement system enables the measurement of receptor targets in whole live cells and the generation of data that is more biorelevant than in other cellular screening systems.

Andy Boorn, President of MDS Sciex said, “We are very excited about the capabilities that the CellKey™ System offers our drug discovery customers, many of whom were involved in providing feedback during its development.”

“We expect that CellKey™ will allow our customers to simplify their assay design activities, address many of the bottlenecks currently experienced within secondary screening and lead optimisation, and ultimately enable them to develop important new medicines more rapidly.”

“The CellKey™ System represents a major breakthrough for receptor measurements, being the first system that can be used to accurately monitor all differently-coupled GPCR’s as well as tyrosine kinase coupled receptors and nuclear receptors on a single platform and using cells that express the receptors at natural levels,” said Simon Pitchford, Vice President of Marketing, Sales and Service.