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Multichannel Pipetting Enables Economic 3D Microtissue Cultivation

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INTEGRA, in association with Insphero (Zurich, Switzerland), have released an application note that describes how a precise pipetting technology enables the efficient use of a hanging drop culture system overcoming many of the drawbacks of conventional cell culture techniques.

Cells cultured in standard suspension or monolayer culture typically lose many features that are characteristic of cells in tissue and limit their use to study certain aspects of cell biology. The major differences to in vivo growth conditions of cells include the absence or limited interaction of cell-cell interaction and cell-matrix interaction, a lack of three-dimensional architectural appearance and changed hormonal, nutritional and physical environment.

The application note describes how Insphero's hanging drop cell culture system is used to generate a diverse range of microtissues. This microtissue system is based on the GravityPlus culture platform for which multichannel pipettes have to be used for liquid media exchange of the culture drops.

INTEGRA VIAFLO pipettes feature a Tri-Lobe tip fitting system (GripTips) which can deliver high lateral resistance ensuring that tips snap securely into place. As a result, GripTips deliver a consistent tip seal ensuring that all tips on a multichannel pipette are in line and at the same height thereby increasing the precision of each multichannel dispense.

For Insphero the tip fitting providing positioning of the tips was one of the key reasons for using the INTEGRA Viaflo pipettes as it guaranteed precise connection of all tips to the bores on their GravityPlus platform.