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New Olympus IX81®-ZDC2 Zero Drift Inverted Microscope Offers Continuous Autofocus for Time-Lapse Imaging

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Olympus has introduced the new IX81®-ZDC2 Zero Drift microscope system, a motorized inverted microscope with a comprehensive, integrated autofocus solution for investigators doing time-lapse experiments.

The IX81-ZDC2 Zero Drift system’s next-generation autofocus system is designed to operate continuously so that it maintains focus even when the events being observed happen quickly and experiments occur over a short timescale.

In addition, the system can be set to operate in a discrete, one-shot mode designed to facilitate applications that require maintaining multiple focus positions, such as experiments involving multi-well imaging. The system is optimized for use with total internal reflectance fluorescence (TIRF) and other advanced applications.

The ZDC2 Zero Drift system uses a Class 1 785nm laser diode to locate either the water/glass interface (for oil- or water-immersion objectives) or the air/glass interface (for non-immersion lenses). Samples can be mounted on coverslips, multi-well tissue culture plates, glass-bottom culture dishes or other glass substrates.

Working in tandem with MetaMorph® for Olympus software, ZDC2 Zero Drift uses an intermediate lens to focus to the desired z-position (depth) in the sample, automatically maintaining focus for seconds, hours, days or weeks. Using its automated continuous mode, users can retain focus even after reagents are added.

The IX81-ZDC2 Zero Drift provides the brightest images possible under time-lapse conditions. It can be used with a broad range of objectives including two key high-transmission Olympus TIRF lenses – the APON 60x, 1.49 NA and the UAPON 100x 1.49 NA objectives.