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Otava and Life Chemicals Present the PI3K Focused Library
Product News

Otava and Life Chemicals Present the PI3K Focused Library

Otava and Life Chemicals Present the PI3K Focused Library
Product News

Otava and Life Chemicals Present the PI3K Focused Library


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Otava and Life Chemicals Inc have presented the human Phosphatidylinositol 3-Kinase focused library with 2189 compounds.

This library has been created as a part of a joint project aimed at design of a large set of receptor-based sharp-focused libraries.

In the framework of this project, Life Chemicals provides its Collection of 300000 compounds and subsequent chemical optimization.

Otava provides its drug-like Green Collection (50000 compounds) and also is responsible for molecular modeling tasks.

Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family.

Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.

In case of this library detection of H-bonding between ligand and key PI3K hinge region residue (Val882) was used for its preparation.

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