We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Tecan’s AC Extraction Plate™ Boosts Productivity for Clozapine Testing

Want a FREE PDF version of This Product News?

Complete the form below and we will email you a PDF version of "Tecan’s AC Extraction Plate™ Boosts Productivity for Clozapine Testing"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

King’s College Hospital, London, has established a fully automated therapeutic drug monitoring protocol for clozapine using Tecan’s AC Extraction Plate™ and Freedom EVO® liquid handling platform.

Lewis Couchman, Senior Clinical Scientist (Clinical Biochemistry Laboratory and Toxicology Department), explained: “We perform about 30,000 tests a year for clozapine, preparing the samples manually by liquid-liquid extraction. We wanted to automate the analytical process, making it more rapid and robust, and less prone to human error - as well as reducing costs and providing the capacity to grow the service - and the AC Extraction Plate and Freedom EVO have the potential to make a real difference to our workflow.”

“Currently, samples arriving at the laboratory by 1 pm are manually extracted during the afternoon, run overnight, and the results reported the following day. The Freedom EVO can prepare a whole AC Extraction Plate in around 30 minutes, followed directly by LC-MS analysis, with a runtime of just under four minutes a sample. We have compared around 500 samples prepared manually and using the automated method, and are really impressed with the results; there is no discrepancy between the two methods. We are in the final stages of the evaluation phase, but everybody is excited at the prospect of seeing it implemented.”