Thermo Continues to Innovate in Mass Spectrometry and Chromatography
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Thermo Electron Corporation has launched several liquid chromatography/mass spectrometry (LC/MS) advancements at the ASMS Conference on Mass Spectrometry in Seattle, Washington: the Accela™ High Speed Chromatography System, the LTQ XL™ Linear Ion Trap Mass Spectrometer with Electron Transfer Dissociation (ETD) for proteomics, the TSQ Quantum™ Access Triple Quadrupole Mass Spectrometer and patented FAIMS Technology for high sensitivity LC/MS/MS quantitation.
"Our customers demand solutions that dramatically streamline or automate their workflows, rapidly analyze volumes of data, and pave the way for the introduction of mass spectrometry beyond the research lab into hospitals, clinics and smaller lab settings around the world," said Ian Jardine, vice president, global research and development, Thermo Electron.
"Over the past 12 months, no company has delivered mass spectrometry innovation at a faster pace than Thermo, and our goal is to continue setting the bar for performance for years to come."
Thermo's advancements launched at ASMS include:
Accela High Speed Chromatography System is designed to operate from conventional to ultra-high pressures, providing separations that integrate with Thermo's ultra fast scanning mass spectrometers.
Accela lets users achieve shorter run times with peak symmetry and data quality.
The system is designed to meet the analytical needs of LC and LC/MS users working in drug development, discovery, QA/QC, academic, and food and beverage laboratories.
LTQ XL Linear Ion Trap Mass Spectrometer extends the benefits of Thermo's LCQ/LTQ family of ion trap mass spectrometers.
The system is designed for drug discovery and proteomic applications, specifically to accelerate screening for drugs, their metabolites, and degradation products.
The instrument includes a number of advanced features including the optional ETD technique for 1) mapping of post-translational modification (PTM) sites, 2) allowing comprehensive proteomic sample profiling, and 3) fragmenting and analyzing large peptide fragments as well as intact proteins.
TSQ Quantum Access Triple Quadrupole Mass Spectrometer is designed for fast, efficient and confident sample analysis in the environmental and food safety markets.
It features QED-MS/MS (Quantitation Enhanced by Data-dependant MS/MS) for simultaneously performing quantitative analysis and generating rich product ion spectra for compound identification.
FAIMS (High-Field Asymmetric Ion Mobility Mass Spectrometry) technology for high-sensitivity bioanalysis, is an option available with Thermo's TSQ Quantum™ triple quadrupole mass spectrometers.
Developed through the R&D efforts at Ionalytics, which Thermo acquired in August of 2005, the patented technology has been demonstrated to help in the development of LC/MS/MS methods for drug quantitation by improving analyte selectivity in complex sample analyses.
Jardine continued, "We believe the addition of FAIMS will contribute tremendously to our customer's ability to push their detection limits even further. This is critical to the acceleration of drug discovery research."
Advanced software packages, including SIEVE, support the critical discovery of protein biomarkers using Thermo's mass spectrometers.
Created in collaboration with the Massachusetts General Hospital at the Biomarker Research Initiatives in Mass Spectrometry (BRIMS) center, SIEVE is a label-free differential expression analysis software offering an automated workflow to compare LC/MS analyses from large sample populations.
Combined with the advanced capabilities of LTQ FT Ultra, as well as LTQ Orbitrap™, the system is designed to provide high-resolution and accurate mass data that allows for automated data processing to conclusively identify and quantitate protein biomarkers.
Thermo's other software introductions include: the MetWorks™ integrated acquisition and analysis; BioWorks™ 3.3 for quantitative proteomics; ProSightPC™; as well as highly stable software like QuickQuan™, LCQUAN™ 2.5, Watson™ LIMS and Galileo LIMS.
