Thermo Scientific Expands RED Line for Drug Discovery Research
Product News Feb 23, 2012
Thermo Fisher Scientific has announced that it has expanded its rapid equilibrium dialysis (RED) line for drug discovery research, adding new molecular weight cutoffs (MWCO) to the popular Thermo Scientific Single-Use RED Device line.
The RED Device is now offered with 12K and 25K MWCO membranes. Previously, these MWCOs were available only as a custom order.
The new molecular weight cutoffs offer more options to researchers working with larger drug candidates such as peptide or siRNA molecules.
The newest RED Devices are specifically designed and extensively validated for plasma serum-binding assays.
The devices can also be used for determining drug partition between red blood cells and plasma, protein binding of liver microsomes to improve the correlation between in vitro and in vivo intrinsic clearance and the competition between tissue protein binding against plasma proteins.
The Single-Use RED Plate is validated for minimal nonspecific binding.
The RED Devices accommodate sample sizes between 100-500 microliters.
The high membrane surface-to-volume ratios of the devices enable rapid dialysis, reaching equilibrium in less than four hours with high levels of reproducibility and accuracy.
The plate format requires no extensive assembly steps or specialized equipment, and each chamber is easily accessible from the top of the device.