Thermo Scientific Introduces Maybridge HitFinder-Plus Screening Compound Library

Thermo Fisher Scientific Inc. has announced Maybridge HitFinder™-Plus, a collection of 3,000 pre-plated drug-like screening compounds that is ideal for a variety of drug discovery programs.

The new library expands the industry leading Maybridge HitFinder collection of 14,400 screening compounds and is available as an “add-on” for current HitFinder users at reduced upgrade fees.

Thermo Fisher created the new HitFinder-Plus collection using an industry standard clustering algorithm, based on standard Daylight Fingerprints and a Tanimoto level of 0.55, to select a statistically representative sample of the full 56,000 compound Maybridge Screening Collection.

All compounds fit Lipinski Ro5 guidelines for "drug-likeness" and have a purity level of greater than 90 percent. They have also been selected to be non-reactive, ensuring fewer false positives and higher-quality results.

When combined, the pre-plated Maybridge HitFinder and HitFinder-Plus collections contain more than 17,400 unique drug-like screening compounds, providing a large, but manageable library that is flexible enough for a range of drug discovery programs.

These pre-selected, diverse collections are conveniently supplied as dry films in Thermo Scientific Matrix 96-shallow-well plates or 384-well microplates.

For further convenience, users can view and assess the exact structures in each plate by browsing the collections online at www.chem.maybridge.com/hitfinder.

This ensures that the process of identifying potential drug leads using Maybridge compounds is as easy and cost-effective as possible.