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Thermo Scientific Introduces Poster Galileo LIMS Achieves in Vitro ADME/Tox Profiling and Screening
Product News

Thermo Scientific Introduces Poster Galileo LIMS Achieves in Vitro ADME/Tox Profiling and Screening

Thermo Scientific Introduces Poster Galileo LIMS Achieves in Vitro ADME/Tox Profiling and Screening
Product News

Thermo Scientific Introduces Poster Galileo LIMS Achieves in Vitro ADME/Tox Profiling and Screening


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Thermo Fisher Scientific Inc. announces the availability of a new technical poster demonstrating the use of its purpose-built Thermo Scientific Galileo LIMS to perform in vitro ADME/Tox profiling.

The new technical poster is available free-of-charge via www.thermo.com/galileo. Thermo Scientific Galileo Laboratory Information Management System (LIMS) provides an integrated, template-driven database system to allow data review and acceptance for large numbers of compounds for a range of ADME/Tox profiling and screening applications such as metabolic stability, IC50, Caco-2 and PAMPA.

The solution enables pharmaceutical and CRO companies to manage data appropriately in order to rapidly execute key decisions on drug candidate selection.

ADME/Tox profiling has become important for drug candidate selection and optimization of a compound's physicochemical properties. Point solutions such as standalone spreadsheet and graphing tools are inefficient, prone to errors and lead to inconsistent results.

Template modifications propagated over time cause variations in data handling and problematic apples to apples comparisons. The lack of a central repository results in data being maintained in disparate locations without traceability. A fully functional database system can reduce effort and manpower required and increase throughput by automating complex experiment templating, instrument interfacing, data analysis as well as review and acceptance tasks.

Thermo Scientific Galileo LIMS can provide simple data processing, graphing, data review and reporting while also facilitating consolidation and automation of multiple processes.

Furthermore, flexible calculation settings can enable laboratories to follow their standard procedures. Moreover, the system is capable of performing automatic re-calculation after outlier data is removal. User-definable calculations using Microsoft Excel spreadsheets are controlled and stored securely in Galileo LIMS database, adding security and allowing GLP compliance if necessary. Users are allowed to set up their own tree-style logic for flagging of results.

The study design of Thermo Scientific Galileo LIMS templates allows specification of key experimental variables including drug and inhibitor concentrations, species, biomatrix, tissue, analytical time points, assay methods and result calculation options. Manual data transfer to external software for processing and storage is virtually eliminated.

Instrument data can be imported via Rapid Study Entry using a simple dialog to populate the template with analytical results and hence automatic calculation of ADME/Tox parameters.

The system's Gallery presents data in tabular, thumbnail or detailed views. The thumbnail view allows users to scan across many datasets while the details view allows users to 'drill-down' into a data set. Results are automatically calculated when the charting galleries are opened and re-calculated whenever outlier points are deactivated.

ADME/Tox parameters can be flagged automatically in the Gallery or in the Details view using green, yellow or red flags to indicate acceptable, questionable or rejected results for each drug candidate.

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