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TTP Labtech Launches chipCAL

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Enhance enzyme discovery and optimization with the new chipCAL, an innovative low cost, low volume flow calorimeter from TTP Labtech.

chipCAL’s fast throughput enables characterization of enzyme activity to be achieved within 2-10 minutes per sample, thus opening the door to high-throughput enzyme screening.

In addition, chipCAL is suitable for monitoring a range of processes in the biopharma, food and fermentation industries. TTP Labtech will showcase chipCAL on booth 3470 at Pittcon, March 11-15th 2012.

TTP Labtech’s innovative technology employs a flow principle, whereby enzyme and substrate are passed through a thermodynamic cell simultaneously.

This allows chipCAL to detect thermodynamic changes using volumes as low as 15 µL, minimizing the amount of valuable sample used per analysis.

chipCAL’s microliter flow calorimetry also provides the additional benefit of non-contact, label-free sample monitoring.

Dr Marcel van Tilborg, Corporate Scientist, DSM Biotechnology Centre, who has been closely involved in pilot studies using chipCAL said “finally it is possible to achieve fast, label-free and absolute activity measurements - a breakthrough for everyone using enzymes who need speed, accuracy and low cost in biological assays."

chipCAL is very easy to use. It has a wide working temperature range of between 15-60 °C, allowing a broad variety of biological activities to be analyzed.

Following analysis, samples are simply passed through to a waste unit and a new sample can be loaded, without the need for a laborious wash stage.

This technology has the potential to significantly enhance high-throughput enzyme screening, being capable of analyzing up to 60 samples in an 8 hour working day.