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Ubiquigent Continues Drug Discovery Collaboration With Bristol Myers Squibb

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Ubiquigent Limited has announced the continuation of a collaboration with Bristol Myers Squibb. The collaboration, originally between Ubiquigent and Celgene, will allow Bristol Myers Squibb to capitalize on the strength and breadth of Ubiquigent’s deubiquitylase (DUB) enzyme inhibitor drug discovery platform and expertise.

The central role of ubiquitylation in diverse cellular processes, including protein degradation, makes the enzymes responsible for ubiquitylation and de-ubiquitylation very attractive drug targets to address a range of human pathologies. Since the clinical approval of proteasome inhibitors, there has been growing interest in modulating the various components of the ubiquitylation machinery, such as DUBs, or exploiting the ubiquitin pathway via PROTACs and molecular glues to target the undruggable genome.

Ubiquigent’s Managing Director, Mr. Jason Mundin commented: “We are delighted to continue this partnership and look forward to supporting Bristol Myers Squibb in the development of novel DUB inhibitors for patients with unmet medical needs.”