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Waters Adds Key Extensions to UPLC Product Portfolio

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Waters Corporation announced has new additions to its growing line of products for UltraPeriormance LC® (UPLC®). The product extensions - including new instruments, chemistries, and features – that were shown for the first time at the 59th Pittsburgh Conference on Analytica Chemistry and Applied Spectroscopy, March 2 - 6, 2008.

New Applications-Specific, UPLC-Based LC-MS Systems:

The new Waters PATROL UPLC Process Analyzer is a real-time online process analytical technology (PAT) system able to detect and quantify complex multiple component manufacturing samples and final product on the production floor.

Designed with the same enabling technology platform as Waters ACQUITY™ UltraPerformance LC™ (UPLC) System, the PATROL UPLC Process Analyzer moves existing liquid chromatography (LC) analysis from off-line quality control (QC) laboratories directly to the manufacturing stream resulting in significant improvements in production efficiency with real-time analysis, reducing both process cycle times and assuring product quality.

The Waters MassTrak™ Amino Acid Analysis (AAA) Solution is the first system to combine Waters ACQUITY UPLC technology with Waters patented AccQTag™ derivatization chemistry for performing amino acid analysis on urine and plasma samples in a research setting.

The system combines a Waters ACQUITY UPLC System and a Quattro PremierT1 XE mass spectrometer for the sensitive and selective determination of contaminants at very low concentrations.

New UPLC Column Chemistries:

At Pittcon 2008, Waters portfolio of UPLC columns continues to grow with the introduction of two new C18 bonded phases for the 1.8 pm High Strength Silica (HSS) UPLC particle.

ACQUITY UPLC HSS C18 columns combine a high coverage, fully endcapped C18 bonded phase with the rugged and efficient HSS particle to produce UPLC columns that provide superior peak shapes, higher retentivity, long column lifetime under acidic conditions, and excellent batch-to-batch reproducibility. This column is available immediately worldwide.

ACQUITY UPLC HSS C18 Selectivity for Bases (SB) columns is the third bonded phase developed for the 1.8 pm High Strength Silica (HSS) particle and the eighth commercially available UPLC column chemistry developed. The ACQUITY UPLC HSS C18 SB column chemistry is designed and optimized specifically to be “different” in terms of selectivity for the analysis of basic compounds under low pH conditions.

ACQUITY UPLC HSS C18 SB columns combine an unendcapped, intermediate ligand density C18 bonded phase with the rugged and efficient HSS particle to produce UPLC columns that provide alternate selectivities for basic compounds under low pH conditions.

VanGuard™ Pre-Columns Chemistries Extensions:

At Pittcon 2007, Waters released VanGuard Pre-Columns which was the first commercially available guard column device designed to protect and prolong UPLC column lifetimes. At Pittcon 2008, Waters announces the availability of additional UPLC column chemistries available for the VanGuard Pre-Column format.

Immediately available UPLC chemistries joining the currently available ACQUITY UPLC BEH C18 chemistry include BEH Shield RP18 HSS T3 and HSS C18. The remaining ACQUITY UPLC chemistries, BEH C8, BEH Phenyl, BEH HILIC and HSS C18 SB will be released and available by mid-2008.