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Dianthus: Take On Challenging Affinity-Based Screening

Dianthus: Take On Challenging Affinity-Based Screening

It’s not surprising that the most important drug candidates and targets are super challenging when it comes to affinity screening. Immobilization-dependent techniques like SPR, and sample-consuming ITC struggle with demanding affinity screening applications such as ternary complexes, multimeric proteins, and intrinsically disordered proteins. These are precisely the applications where Dianthus excels.

Dianthus is a plate-based, microfluidics-free screening platform that requires no surface immobilization, and measures under controlled equilibrium conditions – perfect for challenging affinity screenings. Armed with Dianthus, you have an opportunity to keep your project moving forward when your hit identification or lead optimization involves any of these molecules:

  • Binary and ternary complexes formed by PROTACs and other small molecule degraders
  • Fragment libraries
  • Intrinsically disordered proteins (IDPs) and other aggregation-prone targets
  • Large multicomponent complexes
  • DNA-encoded libraries

Additionally, Dianthus is a great choice if you’re looking for a complementary or orthogonal technique to validate hits and leads identified by other biophysical methods.

About NanoTemper Technologies
At NanoTemper, our vision is to help create a world where every disease is treatable. For us, that starts by equipping scientists with reliable tools that bring them the clarity, confidence, and momentum they need to discover future therapies, even difficult ones.