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Exclusive! BromoTag® Degrader for Target Exploration and Validation
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BromoTag® AGB1 is our new TAG Degrader licensed exclusively to Bio-Techne by the University of Dundee. TAG Degraders are valuable tools for validating targets and use a targeted protein degradation approach that is generalizable to any intracellular target protein.
To facilitate your experiments, we also offer the negative control (BromoTag® cis-AGB1, Cat. No. 7687) and the antibody for detection of BromoTag AGB1-induced degradation of fusion proteins.
Key Features of BromoTag® AGB1
• Highly selective and potent "Bump & Hole" TAG Degrader (DC50, 6h < 15nM) • Recruits VHL to selectively degrade proteins tagged with the mutant BromoTag domain, Brd4BD2 L387A • Suitable for in vitro and in vivo applications
BromoTag® is a registered trademark of the University of Dundee and is used under license.
Description:Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)
Chemical Name:(S)-13-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate
Purity:≥98% (HPLC)
Molecular Weight:1031.68
Size:5 mg
Tag DomainBrd4BD2 L387A
Recruited E3 ligaseVHL
Suitable for in vivo?Yes
Negative control available?Yes
Brd4BD2 L387A Antibody available?Yes
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