GDNF: A Neurotrophic and Neuroprotective Factor

Glial cell line-derived neurotrophic factor (GDNF) plays a vital role in promoting motor neuron survival and axon outgrowth. It is being evaluated in clinical trials as a potential therapeutic for Parkinson’s disease. GFL-like drugs are also being developed to treat disorders such as neuropathic pain and addiction.

GDNF belongs to the GDNF family of ligands (GFLs), which also consists of neurturin (NRTN), artemin (ARTN), and persephin (PSPN). These molecules bind to GFRA1, GFRA2, GFRA3, and GFRA4, respectively. GDNF/GFRA1 complex triggers the phosphorylation of RET tyrosine kinase receptor, ultimately eliciting cell survival, proliferation, and development via the MAPK/ERK or PI3K/Akt pathways. GDNF/GFRA1 also complexes with NCAM to induce axonal expansion. In addition, GDNF can synergize with other growth factors, including transforming growth factor-β (TGF-beta).

Sino Biological has developed an array of recombinant GDNF and GFRA1 proteins and antibodies from various species, such as human, mouse, cynomolgus, rabbit, rat, and canine.