Inositol signaling for Gαq -GPCR studies
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As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very effective for discovering and characterizing new compounds that target GPCRs. Download this white paper to learn about utilizing IP1 to screen the pharmacological potency of compounds. Review the complexities of Gq-coupled GPCR signaling cascades with a highlight on second messengers. Read analysis of the drawbacks of Calcium Flux technology and learn how to minimize false positives. Explore IP-One technology for an efficient, non-radioactive, and easy method for characterizing compounds acting on Gq-coupled receptors.