Opera Phenix High-Content Screening System
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Opera Phenix High-Content Screening System: Speed and Sensitivity – No Compromise
The Opera Phenix™ high-content screening system from PerkinElmer is the premier confocal solution for demanding high content applications. Drawing on over a decade of experience in high content screening, the Opera Phenix enables you to perform high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells, 3D cell cultures and microtissues.
To really benefit from phenotypic screening approaches and complex cellular models, you need more sensitivity to capture more information. And to generate robust results, you need the speed to image numerous cells under varying conditions and measure multiple parameters.
Previously, you had to choose between speed and sensitivity. With the Opera Phenix high-content screening system, simultaneous multicolour confocal image acquisition speed is achieved without compromising sensitivity, because spectral crosstalk is reduced to a minimum. That means higher throughput than ever before and more information-richer data.
Everything You Need from Acquisition to Analysis
The process is made easy by the Harmony™ high-content imaging and analysis software which guides you through and enables you to control every aspect of your experiment via a single, workflow-based user interface.
Phenotypic screening and studies of complex cell models using high-content screening generate massive quantities of data which you need to be able to analyze to turn into knowledge. Harmony has ready-made solutions for common image analysis tasks to get to results fast, and image analysis building blocks so that new high-content analysis protocols can be created, configured and customized. Advanced analysis features such as texture and STAR morphology analysis provide detailed descriptions of cellular phenotypes, enabling more robust and reproducible classification.
You also need to be able to effectively manage all the data you generate from your screens and studies. Harmony software provides automatic storage of metadata, such as assay layout, instrument settings, and analysis results, plus user-defined keywords and annotations.
Advanced Analysis For Better Decisions Sooner
Image data from Opera Phenix can be automatically exported into the Columbus™ Image Data Storage and Analysis System, so that the data can be accessed, reanalyzed, stored, and shared across your lab. You can also export your image data to TIBCO Spotfire® Software, which allows you to aggregate data from multiple sources, perform complex analyses, and create interactive visual dashboards, revealing new insights and correlations.
Automate for Greater Productivity
Add automation to the Opera Phenix for even higher throughput, productivity, and reduced variability. Integrate with the plate::handler™ system for automated plate loading to enable overnight runs, or automate entire high content screening workflows with cell::explorer™ automated workstations.
For best results from high-content screening, consideration must be given to the microplates used. PerkinElmer’s a range of microplates for HCS applications such as the CellCarrier™ Ultra are carefully designed to ensure superior results and have been validated on our high-content systems.