Cell Signaling – News and Features

Researchers identified plasma proteins linked to brain aging using imaging and proteomics. Key biomarkers, like BCAN and GDF15, highlight early molecular signs of cognitive decline and disease risk.

A UT Southwestern trial found selinexor, an FDA-approved drug, effective in KRAS-mutated non-small cell lung cancer (NSCLC). Combined with chemotherapy, it achieved tumor control in 80% of cases.

UF Health researchers found that a toxin in Campylobacter jejuni accelerates colorectal cancer metastasis, linking gut bacteria to cancer spread. The study revealed how the toxin activates metastasis-associated signaling pathways.

Researchers have discovered that the armlike structure of mammalian brain cells may be a different shape than previously thought.

A study identifies "proteolethargy," reduced protein mobility caused by oxidative stress, as a unifying mechanism in chronic diseases. The findings suggest that impaired protein movement disrupts cellular functions.

A University of Liverpool study links Alzheimer’s disease to disrupted mechanical signaling between proteins APP and talin in synapses. This misprocessing destabilizes synaptic integrity, leading to memory loss.

Researchers identified that the interaction between proteins Rab7a and TPC2 promotes melanoma growth and metastasis by altering endolysosomal processes and key signaling pathways. Inhibiting Rab7a reduces TPC2 activity, suppressing tumor progression.

University of Bonn researchers developed a new technique to study immune cell receptors, Toll-like receptors (TLRs), which detect infections. This method, using changes in light wavelength, reveals how TLRs respond differently to distinct signals.

Researchers discovered that cordycepin, derived from the caterpillar fungus Cordyceps militaris, disrupts cancer cell growth by interfering with signaling pathways. The compound converts to cordycepin triphosphate within cells, mimicking ATP.

A study by USC researchers found that PFAS exposure is associated with reduced kidney function in young adults, with disruptions in the gut microbiome and related metabolites potentially explaining up to 50% of this decline.