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Drug Kinetics – Multimedia

Safety Considerations for the Development of Antibody Drug Conjugates
Video
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Safety Considerations for the Development of Antibody Drug Conjugates

Both the antibody and small molecule of an ADC can contribute to drug interactions, so they should be considered from a safety perspective. However, regulatory guidance is not well established. Here’s what you need to know.
Rapid Quantitation of AAV Capsids in Bioprocess Development for Gene Therapy Using Octet®️ BLI
Video

Rapid Quantitation of AAV Capsids in Bioprocess Development for Gene Therapy Using Octet®️ BLI

Accelerate bioprocessing in gene therapy. Adeno-associated virus (AAV) capsid quantitation in as little as 15 minutes using Octet® BLI systems. Compare the Octet® AAVX biosensor workflow to that of ELISA at various stages in bioprocess development.
Accelerate Throughput and Discovery for Your Mass Spec Imaging Projects
Video

Accelerate Throughput and Discovery for Your Mass Spec Imaging Projects

With unparalleled speed, sensitivity and spatial resolution, Shimadzu’s iMScope QT imaging mass microscope clears the way to next-generation mass spectrometry imaging in areas such as biomarker tracking, pharmacokinetics, and ADME studies.
Kinetic Analysis
Poster

Kinetic Analysis: Spotting the Weakest Binders

Designing and performing assays that accurately measure small molecule binding kinetics is an important part of the drug discovery process. It allows researchers to predict the efficacy of potential novel therapeutics and make quick decisions about weak binders.
Revolutionary Binding Kinetics Analysis content piece image
How To Guide

Revolutionary Binding Kinetics Analysis

Conventional bioassays often require labeled detection reagents to provide a measurable readout. However, modifications to molecular structure and/or function can skew results, and non-specific binding of the labels themselves can lead to an unwanted background signal.
Design Intricacies and Decision Making Strategy for Drug Drug Interaction Studies content piece image
Video

Design Intricacies and Decision Making Strategy for Drug Drug Interaction Studies

Conducting in vitro ADME drug-drug interaction (DDI) studies early on in the drug development process is more than simply a box checking exercise to satisfy regulatory requirements. The information provided by these studies provides a deeper understanding of the molecule to the drug developer helping to inform go or no-go decisions early on.
Video

Highlights of the In Vitro Sections of the Draft ICH Drug Interaction Studies Guideline and Comparison with Current Guidance

Hear expert Dr. Brian Ogilvie discuss the differences between current in vitro drug-drug interaction guidance from the relevant US FDA, EMA and PMDA guidance documents, and how to plan drug development strategies to meet the ICH M12 guideline.
Filing an IND and Beyond: Development of CTD Section 2.6.4, Pharmacokinetics Written Summary content piece image
Video

Filing an IND and Beyond: Development of CTD Section 2.6.4, Pharmacokinetics Written Summary

This presentation was one of the keynote presentations from XenoTech's XenoTalks™ Seminar Series on the importance of ADME and Drug-Drug Interactions in drug development.
Model-Based Approaches to DDI Risk Prediction-Transitioning from In Vitro Data to In Silico Modeling content piece image
Video

Model-Based Approaches to DDI Risk Prediction-Transitioning from In Vitro Data to In Silico Modeling

This informative ADME 101 discusses In Vitro to In Vivo Extrapolation (IVIVE) and how a model-based approach following routine perpetrator potential studies (i.e. CYP inhibition, CYP induction, and transporter inhibition) assessing clinical potential may eliminate the need of conducting clinical studies.
Advances in High Throughput Analysis of In-Vitro Drug Screening Using the Novel Echo® MS System content piece image
Video

Advances in High Throughput Analysis of In-Vitro Drug Screening Using the Novel Echo® MS System

Speaking at Advances in Drug Discovery & Development online symposium 2021, Rolf Kern from SCIEX, presented his talk on the new Echo MS system.
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