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Drug Targets – News and Features

A target over a cancer cell.
News

Pancreatic Cancer Protein Targeted by Protein Degraders

University of California, Riverside scientists have designed novel agents that bind to and degrade Pin1, a protein linked to pancreatic cancer. These “molecular crowbars” destabilize Pin1, making it vulnerable to degradation.
A plastic model of a human brain, bisected to show internal structures, with a brain cell next to it.
News

Microglia Exacerbate Damage in APOE4 Model of Alzheimer’s

New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.
A 3D model of a human brain.
News

New Clusters of Cells Identified in the Human Amygdala

Scientists at UC Davis discovered new gene expression clusters in the amygdala of humans and non-human primates, enhancing understanding of emotional disorders. This research may open pathways for developing targeted therapies for anxiety.
Small round white pills on a blue background.
News

Experimental Drug Triggers Rapid Cell Death in Cancer Models

Researchers have designed a small molecule that holds promise as a cancer therapeutic, activating the apoptosis cascade in tumor cells while sparing healthy cells.
Collage of the headshots of eleven Black scientists featured in the article.
Article

Reclaiming the Narrative for Black Scientists

This article highlights several inspiring men and women working across academia and industry who are breaking barriers and regaining ownership of their own narratives.
Colon cancer cells, labelled in red and green.
News

Cancer Risk Linked to “Guardian of the Genome” in Ulcerative Colitis

Researchers have shed new light on the role of p53 in the pathogenesis of ulcerative colitis, which is linked to an increased colon cancer risk.
Blister packets of different medications
News

Experimental Cancer Drug Suppresses Breast Cancer Bone Metastases

In a new study, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.
Cells.
News

Diabetes-Linked DNA Changes Disrupt Pancreatic Cells’ Stress Resilience

Research identifies how DNA sequence changes linked to diabetes risk affect pancreatic cell stress responses. The study shows that stressors like inflammation and high blood sugar can overwhelm insulin-producing cells.
RNA Polymerase II transcribing DNA into RNA.
Industry Insight

Getting New Drug Modalities to Market: How Can Your Data Strategy Help?

This article explores the revolution in new drug modalities and the challenges around effective data strategies to support AI efforts.
A glowing award icon.
Industry Insight

Innovation Award Winner Announced at ELRIG Drug Discovery 2024

Technology Networks had the pleasure of speaking with the ELRIG Innovation Award Winner Constructive Bio’s CEO, Dr. Ola Wlodek, to discuss its award-winning innovations and learn more about its mission.
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