High-Throughput Screening – News and Features

Chemists have created a new methodology that rapidly generates millions of combinations of small molecules through programmed assembly using DNA-pairing processes.

Cancer biologist Yibin Kang has been investigating the gene MTDH, which enables cancer in two ways. He has found a way to disable the gene in both mice and in human tissue, with a targeted experimental therapy.

Researchers have developed a 3D cell culturing platform that allows the study of lung fibroblasts and their microenvironment. The platform enables measurement of cell behaviors and changes involved in the progression of idiopathic pulmonary fibrosis.

This article will explore how high-throughput technologies are continuing to advance research in the life sciences. It will also and highlight various areas directly benefiting, including drug discovery, genomics and molecular biology.

To learn more about Life Chemicals and the services it provides, Technology Networks spoke with Olga Balabon. In this interview, Olga also highlights how the company supports researchers when searching for appropriate product candidates.

In this article, we discuss organoids in the context of personalized medicine and infectious disease and explore how they provide a new window into disease and fuel the discovery of new therapeutics.

This article highlights some of the different screening strategies used during drug discovery. Key advances and challenges associated with the techniques are also discussed.

In a preclinical study published in Glia, researchers report that the small molecule drug SRI-42127 can potently reduce the triggers of neuroinflammation.

A research team from Nanjing University has used cochlear organoids to identify drugs that can promote the regeneration of hair cells. The study, published in Stem Cell Reports, also identifies a signaling pathway as a potential target for hearing restoration.

Although the COVID-19 pandemic is unprecedented in scope, researchers have met this challenge by developing a suite of preventive and therapeutic strategies to combat the virus. This article explores the development of nanobody- and antibody-based therapeutics against SARS-CoV-2.