High-Throughput Screening – News and Features

The use of human liver microtissues (hLiMTs) cultured in a 384-well microplate system was explored as a predictive model for assessing drug-induced liver injury (DILI) with promising results.

Researchers discovered that cordycepin, derived from the caterpillar fungus Cordyceps militaris, disrupts cancer cell growth by interfering with signaling pathways. The compound converts to cordycepin triphosphate within cells, mimicking ATP.

Technology Networks asked a selection of startups featured in the ELRIG Drug Discovery 2024 Breakthrough Zone how their technology might reshape the pharmaceutical industry and pave the way for the next generation of therapeutic discovery.

A study by EPFL shows how Pseudomonas aeruginosa manages the trade-off between biofilm formation for antibiotic protection and a mobile state to spread in the lungs.

Technology Networks asked a selection of start-up companies at ELRIG Drug Discovery how their technology addresses key limitations in traditional disease models.

A new study has measured the toxicity of several types of PFAS, better known as “forever chemicals,” when mixed together in the environment and in the human body.

A UCLA team created a biobank of sarcoma organoids from 126 patients, enabling rapid drug screening. The organoids retained tumor characteristics, allowing identification of effective FDA-approved treatments for 59% of samples.

High concentrations of organic micropollutants caused the death of fish, mussels and snails in the Oder river in 2022 by exacerbating the lethal effects of an algal toxin.

In this interview, Tola Olorunnisola, senior vice president and general manager at Avantor, delves into how AI and automation could put the Lab of the Future within our grasp, enabling scientific breakthroughs and revolutionizing the drug development process.

The ability to obtain pure proteins is essential for developing drugs, creating vaccines and understanding biological processes. In this article, we discuss what a typical protein purification protocol involves and the various techniques used.