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High-Throughput Screening – News and Features

Cancer cells.

Promising Early Trial Results for Second-Generation Cancer Therapy

Preliminary results of a study show that a novel, selective inhibitor of protein arginine methyltransferase 5 demonstrated antitumor activity in patients with advanced malignant solid tumors or B cell non-Hodgkin lymphomas.
A picture of medicines.
Industry Insight

Failing Faster To Succeed Sooner in Drug Discovery

Revvity announced its newly established Scientific Centre of Excellence in Cambridge, where scientists can outsource their research needs to Revvity experts. Technology Networks visited the site to learn more about how Revvity is supporting its customers in their drug discovery efforts.
Pink tablets in a blister pack.

Existing Cancer Drug May Be Repurposed for Other Aggressive Cancers

A team of researchers has identified an existing cancer drug that could also be used to treat an aggressive subset of cancers.
Lipid nanoparticle mRNA vaccine.

High-Throughput Formulation Screening To Fine-Tune Performance Characteristics of Nanomedicines

This article discusses how marrying microfluidics with automation can provide the necessary level of control to perform high‑throughput LNP formulation screening in a cost-effective and timely manner, and how this approach can accelerate the development of new nanomedicines.
A human hand and robotic hand touch a strand of DNA.

AI Can Predict Activity of RNA-Targeting CRISPR Tools

A new study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways.
A person putting sweetener in their drink.

Artificial Sweetener Metabolite Breaks DNA

Scientists at the North Carolina State University found that a chemical compound produced through the digestion of a common artificial sweetener causes damage to DNA.
A computer-generated image of a cell.

Probe Developed That Could Reveal Insights Into Key Cellular Messenger

A ground-breaking study has led to the development of a small molecule probe that could improve our understanding of an important cellular messenger.
Floating antibodies

Recent Advances in Therapeutic Antibody Screening

This article explores the various screening technologies used in the development of therapeutic antibodies and outlines the recent advances in this area.
Cisplatin pills.

Compound Prevents Kidney Toxicity Caused by Chemotherapy Drug

Researchers in Japan identify a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment.
Floating cancer cells.

Protein Hyperactivation Could Kill Cancer Cells and Bacteria

Technology Networks had the pleasure of speaking with Walid A. Houry, professor of biochemistry at the University of Toronto, to find out about the discovery of compounds that can induce protease hyperactivation to kill cancer cells.