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Multiomics – News and Features

A stem cell dividing in two with other cells and DNA helices in the background

Unmasking the True Identity of Gut Stem Cells

Columbia researchers have found that Lgr5+ cells descend from the gut’s true stem cells. This case of mistaken identity may explain why regenerative medicine has not lived up to its promise.
A 3D model of a human brain.

RNA Editing Differs in Living vs Postmortem Brains

Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods of RNA editing, a critical mechanism underlying brain development and disease.
White, blue and grey icons on a blue background representing the future of drug discovery. Icons include pie charts, a DNA double helix, a drug capsule, artificial intelligence and cells.

How AI Is (So Close to) Transforming Drug Discovery

In this opinion piece, Markus Gershater provides a comprehensive look into the current state and immense potential of artificial intelligence in reshaping the landscape of drug discovery.
Cortical mouse nerve cells.

Subtypes and Sex Differences Discovered in ALS

Amyotrophic lateral sclerosis (ALS) is an almost always fatal neurodegenerative disease. Researchers have now discovered that ALS can be divided into subtypes and that there are clear differences in the molecular processes between men and women.
An astronaut by a flag on the moon.

Microgravity Shrinks Astronaut Kidneys

The structure and function of the kidneys is altered by space flight, with galactic radiation causing permanent damage that would jeopardise any mission to Mars, according to a new study led by researchers from UCL.
An old person holds their hands in their lap.

Multiomics Approach Identifies Four Distinct Molecular Profiles of Alzheimer’s

A multiomics approach has identified four distinct molecular profiles of Alzheimer's, one of which was associated with worse cognitive function.
John Lesica, president, chromatography and mass spectrometry at Thermo Fisher Scientific.
Industry Insight

Optimizing Analytical Tools To Accelerate Translational Research

John Lesica, president of chromatography and mass spectrometry at Thermo Fisher Scientific, joined Technology Networks for an interview at this year's American Society for Mass Spectrometry event.
A green field.

CRISPR-Cas9 Editing in Plants: What's the Latest Research?

In this article, we take a look at the latest advancements in research applying multiplex CRISPR-Cas9 genome editing to plants.
A mother and her baby.

Digital Babies Created To Simulate the First 180 Days of Life

Whole-body models (WBMs) are computational models that integrate different types of multiomics data such as genomic, metabolic and proteomic insights, and have been created to simulate and study adult physiology and disease. WBMs for newborns, however, are currently lacking – until now.
A scientist places a sample under a microscope

Machine Learning Reveals Key Differences in Inner Workings of Immune Cells

Thanks to a particular cellular architecture, more than half of all killer T cells are able to mount a faster and stronger response to pathogens.