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Pharmacovigilance – News and Features

Two photos, one of a sparrow and one of two zebrafinches.

Harnessing Bird Retrotransposon To Improve Gene Therapy

A new approach uses a retrotransposon from birds to insert genes into "safe harbors" in the genome, holding promise for gene therapy.
Gold particles.

Gold Nanocrystal Treatment Shows Promise for Neurodegenerative Diseases

Gold nanocrystals suspended in a water buffer represent a novel therapeutic agent for neurodegenerative conditions. This nanomedicine, called CNM-Au8, is being investigated to treat patients with multiple sclerosis and Parkinson’s disease.
A person pouring a bottle of pills into their hand.

Model Identifies Potential Drug Combinations To Avoid

A new model has been designed to identify drugs that should not be prescribed together. It has already identified common drugs – an antibiotic and a blood thinner – that may interfere with each other.
High-protein foods.

High-Protein Diet Could Drive Heart Disease

A new study published in Nature Metabolism investigated the potentially adverse effects of a high protein diet, which is often promoted as a “healthy lifestyle”.
Two sheets of graphene.

First Human Trial Shows “Wonder” Material Is Safe To Develop

A revolutionary nanomaterial with huge potential to tackle multiple global challenges could be developed further without acute risk to human health, research suggests.
A 3D model of a human heart.

Common B Vitamin Linked to Heart Disease

Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.
Melanoma cells, with different proteins tagged in yellow, blue, green and red.

Promising Cell Therapy Target Has Strong Response Against Melanoma

A new CAR T-cell therapy that targets cells with high levels of TYRP1 has shown promise against melanoma in preclinical trials.
Double helix structure of DNA.

Genetic Therapy Shows Promise for ALS and Dementia in Animal Models

Macquarie University neuroscientists have developed a single-dose genetic medicine that has been proven to halt the progression of both motor neurone disease (MND) and frontotemporal dementia (FTD) in mice.
A pregnant woman talking a pill.

Antidepressant Use During Pregnancy Impacts Fetal Brain Development

A new study provides direct evidence that antidepressant use during pregnancy can impact a child’s brain development and contribute to the risk of mental health disorders later in life.
Viagra pills on a yellow background.

Erectile Dysfunction Drug Could Help Treat Oxygen-Deprived Newborns

Treatments to help babies who run out of oxygen during pregnancy or at birth are limited. Therapeutic hypothermia is the only option used to prevent brain damage in such cases, but 29% of babies who receive it still develop neurological sequelae.