Pharmacovigilance – News and Features

Article
Addressing Widening Health Disparities With Inclusive Stem Cell Models
Racial disparities in mortality are increasing. This article explores how the production of DNA-edited ethnically diverse stem cell lines for disease research could improve global health equity.

Article
Nanoparticle-Delivered Pain Medication Could Help Address the Opioid Crisis
Professor Dame Ijeoma Uchegbu discusses the nanoparticle delivery system behind the non-addictive pain medication Envelta and how this treatment could help overcome issues surrounding efficacy and off-target effects.

News
Machine Learning Predicts Protein Behavior, Aiding Drug Design
Researchers developed ProtGPS, an AI tool that predicts protein localization in cells and how mutations affect disease. The model identifies functional disruptions and designs novel proteins for targeted therapies.

Article
Organoids, Beyond the Hype
The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of these models, ultimately increasing drug testing accuracy and revolutionizing biomedical science.

News
“All-Tablet” Treatment Shows Promise for Common Form of Leukemia
An international study of over 800 chronic lymphocytic leukemia (CLL) patients found that an all-tablet therapy of acalabrutinib-venetoclax – with or without obinutuzumab –improved progression-free survival compared to chemotherapy.

News
Researchers Find Better Treatment for Rare Pregnancy-Related Cancer
Scientists have found a way to combat a rare, aggressive form of cancer affecting pregnant women and to better ensure the drug used for the disease reaches tumor cells without damaging healthy tissue.

News
Cancer Vaccine Shows Promise for Advanced Kidney Cancer
A phase 1 trial of a personalized cancer vaccine for stage III/IV clear cell renal cell carcinoma showed promising results. The vaccine trained patients’ immune systems to target cancer cells, preventing recurrence.

News
Study Finds No Evidence CAR T-Cell Therapy Causes Secondary Cancers
A study of 783 patients treated with CAR T cell therapy found no evidence that the therapy itself caused secondary cancers. Researchers confirmed that rare cases of cancer were linked to prior treatments like chemotherapy, not CAR T therapy.

News
Gene Therapy Shows Promise for Rare Bone Disease in Mice
Researchers have developed a gene therapy that may provide a long-term treatment for hypophosphatasia. Unlike current therapies requiring frequent injections, this approach delivers a single dose to restore bone mineralization.

News
ApoB100's Shape and Structure Revealed for the First Time
Using cryo-electron microscopy and AI, researchers at the University of Missouri have mapped ApoB100, a key protein in LDL cholesterol. This offers a clearer understanding of cholesterol metabolism.
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