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Pharmacovigilance – News and Features

Gloved hands interlocking wrists, symbolizing collaboration in a laboratory setting
Article

Addressing Widening Health Disparities With Inclusive Stem Cell Models

Racial disparities in mortality are increasing. This article explores how the production of DNA-edited ethnically diverse stem cell lines for disease research could improve global health equity.
White pills on brain MRI scans, symbolizing nanoparticle drug delivery systems for non-addictive pain treatments
Article

Nanoparticle-Delivered Pain Medication Could Help Address the Opioid Crisis

Professor Dame Ijeoma Uchegbu discusses the nanoparticle delivery system behind the non-addictive pain medication Envelta and how this treatment could help overcome issues surrounding efficacy and off-target effects.
A hand outstretched with a graphic representing AI above it.
News

Machine Learning Predicts Protein Behavior, Aiding Drug Design

Researchers developed ProtGPS, an AI tool that predicts protein localization in cells and how mutations affect disease. The model identifies functional disruptions and designs novel proteins for targeted therapies.
Outline of the human body and some of the tissues within, indicating with expanded images ones that organoids may be created for
Article

Organoids, Beyond the Hype

The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of these models, ultimately increasing drug testing accuracy and revolutionizing biomedical science.
Cancer cells.
News

“All-Tablet” Treatment Shows Promise for Common Form of Leukemia

An international study of over 800 chronic lymphocytic leukemia (CLL) patients found that an all-tablet therapy of acalabrutinib-venetoclax – with or without obinutuzumab –improved progression-free survival compared to chemotherapy.
Pregnant woman holding stomach
News

Researchers Find Better Treatment for Rare Pregnancy-Related Cancer

Scientists have found a way to combat a rare, aggressive form of cancer affecting pregnant women and to better ensure the drug used for the disease reaches tumor cells without damaging healthy tissue.
A needle piercing a vaccine vial.
News

Cancer Vaccine Shows Promise for Advanced Kidney Cancer

A phase 1 trial of a personalized cancer vaccine for stage III/IV clear cell renal cell carcinoma showed promising results. The vaccine trained patients’ immune systems to target cancer cells, preventing recurrence.
Cell therapy.
News

Study Finds No Evidence CAR T-Cell Therapy Causes Secondary Cancers

A study of 783 patients treated with CAR T cell therapy found no evidence that the therapy itself caused secondary cancers. Researchers confirmed that rare cases of cancer were linked to prior treatments like chemotherapy, not CAR T therapy.
Double helix structure of DNA.
News

Gene Therapy Shows Promise for Rare Bone Disease in Mice

Researchers have developed a gene therapy that may provide a long-term treatment for hypophosphatasia. Unlike current therapies requiring frequent injections, this approach delivers a single dose to restore bone mineralization.
A 3D model of a human heart.
News

ApoB100's Shape and Structure Revealed for the First Time

Using cryo-electron microscopy and AI, researchers at the University of Missouri have mapped ApoB100, a key protein in LDL cholesterol. This offers a clearer understanding of cholesterol metabolism.
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