Pharmacovigilance – News and Features

Research into cancer-associated fibroblasts could make cancer immunotherapy more effective.

The new WHO-approved MDR-TB treatment BPaL(M) offers hope for tuberculosis patients but is already encountering resistance. A global study identified resistant strains and highlighted rapid transmission risks.

Researchers successfully repaired damaged mouse hearts using a protein from zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

University of Arizona researchers uncovered how levodopa-induced dyskinesia disrupts motor cortex function in Parkinson’s patients. Exploring ketamine as a treatment, they found it promotes neuroplasticity and restores control over movement.

CAR T cells that have a "memory" of antigens previously encountered may be more effective at killing cancer.

The use of human liver microtissues (hLiMTs) cultured in a 384-well microplate system was explored as a predictive model for assessing drug-induced liver injury (DILI) with promising results.

Impurities in pharmaceuticals are a major concern for drug manufacturers. This article will discuss the importance of monitoring and minimizing impurities in drug substances and products and key developments in the field.

Oleanolic acid, found in grapes, could increase the effectiveness of chemotherapy, reducing the amount of drug needed.

New research by Oregon Health & Science University scientists has uncovered multiple factors to improve gene delivery to the kidney by adeno-associated virus vectors.

A University of Queensland study shows no link between childhood exposure to fluoridated water and negative cognitive outcomes. Researchers assessed IQs of 357 participants aged 16–26 and found no adverse effects.