Pharmacovigilance – News and Features

New research by Oregon Health & Science University scientists has uncovered multiple factors to improve gene delivery to the kidney by adeno-associated virus vectors.

A University of Queensland study shows no link between childhood exposure to fluoridated water and negative cognitive outcomes. Researchers assessed IQs of 357 participants aged 16–26 and found no adverse effects.

A study reveals how serotonin-producing neurons in the brain, influenced by GABA and dopamine, regulate meal initiation. The findings explain how hunger inhibits serotonin to trigger eating, while satiety increases serotonin to suppress food intake.

A chemogenetic tool could form the basis of a gene therapy for chronic pain by turning off pain receptors.

Research has shown that COVID-19 pandemic lockdowns impacted people's immune response to microorganisms. During the lockdown, inflammation levels in the body were low, but afterward, the immune system responded more strongly to viruses.

City of Hope researchers discovered YTHDF2, a protein enabling blood cancers to evade CAR T cell therapy by hiding critical antigens. They developed CCI-38, a compound that suppresses YTHDF2, enhancing CAR T therapy's success.

Cell and gene therapies are revolutionizing medicine. Looking to 2025, advancements in allogeneic therapies, streamlined autologous processes and broader applications promise increased accessibility and innovation in treating complex diseases.

Two independent studies have linked the diabetes drug Ozempic with an increased risk of damage to the optic nerve.

The pathogen that causes sepsis has thwarted vaccines, but researchers now know why.

New research shows that body-weight control in mice is strongly modulated by neurons in the nucleus accumbens, a region of the brain that’s rich in endocannabinoids and that helps regulate food reward and physical activity.