Psychedelics – News and Features

Researchers show that it is feasible to substantially extend the antidepressant action of a single dose of ketamine from its current duration of up to a week to a longer period of up to two months.

Research reveals that ketamine stabilizes brain activity in a dose-dependent way. The study used high-density EEG to track changes in brain stability, suggesting ketamine’s effects on brain dynamics might be central to its therapeutic use.

A team of archaeologists discovered ancient snuff tubes carved from hollow bones at the heart of monumental stone structures at Chavín de Huántar, a prehistoric ceremonial site in the mountains of Peru.

In a pilot study testing psilocybin therapy in Parkinson's patients, the participants experienced clinically significant improvements in mood, cognition and motor function that lasted for weeks after the drug was out of their systems.

Mass General Brigham researchers found that immune cells influence brain communication in response to stress, driving fear behaviors. Psychedelic treatments like MDMA and psilocybin reduced fear in preclinical models and human tissue.

A new study from the University of Michigan reveals that psychedelic compounds can improve cognitive flexibility in mice, with benefits lasting for weeks. The findings suggest potential treatments for psychiatric conditions like depression and PTSD.

Use of psilocybin, the hallucinogenic chemical found in what is known as “magic mushrooms,” has increased significantly nationwide since 2019, according to a new study.

UC Davis researchers developed JRT, a modified version of LSD that promotes neuroplasticity without hallucinogenic effects. Tested in mice, JRT enhanced brain connectivity, showed antidepressant effects and improved cognition.

Cornell researchers found that psilocybin’s therapeutic benefits depend on the pyramidal tract neurons and the serotonin 5-HT2A receptor in the medial frontal cortex. Targeting these mechanisms could allow psilocybin to treat depression.

A study found that psychedelic experiences enhanced relationship quality, sexual attraction and intimacy. Participants reported both short- and long-term benefits, with some experiencing changes in gender identity.