Single-Cell Analysis – News and Features

University of Alabama researchers reveal a key mechanism in BK polyomavirus replication, challenging existing models. The virus relies on host cell DNA replication, with its TAg protein expressed only after the first replication round.

A study uncovers that CD8+ T cells in ME/CFS patients exhibit exhaustion-like states, a condition linked to chronic immune activation. This discovery raises the possibility of adapting cancer immunotherapies to reverse T cell exhaustion in ME/CFS.

Researchers have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher-risk version of the disease and are more likely to relapse despite treatment.

Researchers mapped gene expression across the mouse intestine, revealing its stability and adaptability to changes like inflammation. The study identified immune-controlled regions and resilient spatial patterns.

A thymus atlas reveals that immune foundations are set as early as 12 weeks post-conception. Researchers uncovered key T cell development processes, offering insights for engineering immune cells to treat cancer and autoimmune diseases.

A study reveals that 3% of normal breast cells in healthy women have chromosomal abnormalities linked to invasive breast cancer, challenging current cancer detection methods. Aneuploid cells accumulate with age and mimic invasive cancer profiles.

New research provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

T-cell dysfunction linked to obesity prevents T cells from detecting tumor cells, increasing cancer risk.

Researchers at the Max Perutz Labs have uncovered how marine worms regenerate lost body segments. The study reveals that differentiated cells dedifferentiate into a stem cell-like state to rebuild a growth zone.

Researchers at the University of Cincinnati found that copper accumulation fuels renal cell carcinoma by enhancing energy production in tumors. Elevated copper levels activate protective mechanisms that support cancer cell survival.