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Spatial Biology – News and Features

Two cytotoxic T cells attack a cancer cell.

Stem Cell-Derived Therapy Shows Early Promise for Resistant Liver Cancer

An innovative new stem cell-derived therapy could be used to better target and treat the most common form of liver cancer.
A person undergoing intravenous therapy

Potential Therapeutic Target Could Boost Pancreatic Cancer Chemotherapy and Reduce Spread

A research team has discovered that nidogen-2 reduces the dense scaffolding tissue within pancreatic tumors, which is a major barrier to treatment and contributes to the cancer’s well-known chemotherapy resistance.
A pregnant woman sits in an armchair in front of a dog.

Pregnancy and Cancer Share a Common Immune Suppression Mechanism

A mechanism called B7-H4 plays an active role in moderating the immune system in both the placenta and the tumor microenvironment. According to research, blocking B7-H4 slows cancer’s growth.
The outline of an immune cell, filled with words describing immune-mediated condtions.

Novel Gene Expression Technology Discovers Rare T Cells Associated With Autoimmune Disease

Scientists have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma.
3D structure of a melanoma cell derived by ion abrasion scanning electron microscopy.

New Mechanism Behind Melanoma Treatment Resistance Uncovered

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team has now discovered that a factor secreted by tumor cells is responsible for the resistance.
A gloved hand placing a vial inside an LC-MS instrument.

Mass Spectrometry Imaging in Pharmaceutical Development

In this article, we explore how mass spectrometry imaging technology is evolving into a high-resolution spatial biology toolset to transform drug discovery and development.
A COVID-19 protein.

Why Don’t Some People Get COVID-19?

Using single-cell sequencing technology, researchers provide the most comprehensive timeline to date of how the body responds to SARS-CoV-2 exposure.
Cancer cells.

Fasting Primes Immune Cells to Better Fight Cancer, Mouse Study Finds

Periods of fasting reprogram the immune system’s natural killer cells to better fight cancer, according to a new study in mice from researchers at Memorial Sloan Kettering Cancer Center (MSK).
Immunotherapy attacking a cancer cell.

Reinvigorating Exhausted Immune Cells May Kickstart Anti-Cancer Therapy

Researchers at The Jackson Laboratory have not only identified how two immune cells work together to fight cancer but also revealed the cascade of molecules that help coordinate this attack.
Tumor microenvironment.

“Unexpected” Kidney Cancer Drug Resistance Mechanism Uncovered

For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center’s Kidney Cancer Program sheds light