Spatial Biology – News and Features

Researchers have demonstrated that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment.

A study shows how a class of drugs, HDACi (histone deacetylase inhibitors), protects neurons and limits brain damage following stroke by altering the gene expression of microglia, the immune cells of the brain.

A new spatial transcriptomics analysis resource is helping scientists explore how genes behave differently in various parts of the body. This could help to zero in on exact biological processes that could be targeted to treat disease.

A new method combines microscopy with single-cell RNA analysis to make the technique more accessible and scalable, giving researchers an advantage in the numbers game of single-cell analysis.

Scientists have identified the discrete group of co-activated neurons in the brain that work to suppress binge drinking behaviors. This could become a new therapeutic target for alcohol dependency.

Researchers have demonstrated that the presence of a specific "microbial signature" in the microbiome is an accurate indication of colorectal cancer. This insight could lead to more accurate non-invasive screening methods in the future.

A new study from researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine provides fresh insights into how cancers evolve when they metastasize.

Today, single-cell technologies are not only dissecting genomic, transcriptomic and proteomic profiles but also enabling dynamic measurements of cellular functions. Bruker's new Beacon Discovery Platform could make this a reality for more labs.

Researchers have identified a new biomarker, TTF-1, that was predictive of survival outcomes for patients with advanced KRAS G12C-mutated non-small cell lung cancer following treatment with the KRAS-targeted therapy, sotorasib.

Researchers have investigated the emergence of cellular diversity in cancer cells in real time, over several generations.