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Spatial Biology – News and Features

Ocular Fibrosis, 3D Cell Culture Image, spherical microscopy image with various colors.
Industry Insight

Bridging Academia and Industry: The Evolution of 3D Models in Drug Development

The industry's search for alternatives to traditional preclinical drug testing methods has led to a growing interest in the potential of three-dimensional (3D) in vitro models. To delve deeper into this subject, Technology Networks spoke with Madhu Lal-Nag, chief scientific officer at InSphero, a 3D in vitro model company with a mission to “modernize drug discovery in ways that inspire researchers everywhere to reach their full potential and fuel a new era of breakthrough therapies.”
A woman holding her stomach in pain.
News

Endometriosis: What’s the Latest Research?

Endometriosis represents a multifaceted challenge affecting millions of individuals globally. Recent studies have massively advanced our understanding of how the condition affects individuals and is helping to improve the lives of those affected.
Cancer cells.
News

Evolution of Urinary Tract Cancer Cells Mapped

Researchers at Weill Cornell Medicine have performed the most comprehensive analysis to date of cancer of the ureters or the urine-collection cavities in the kidney, known as upper tract urothelial carcinoma (UTUC).
T cells.
News

Why Do Some Immune Cells Lose Energy in Solid Tumors?

New research has unveiled new clues behind T-cell metabolism, that could enhance immunotherapies that rely on T cells to fight cancer.
A syringe filled with liquid is balanced on two empty syringes.
News

“Dramatic” Brain Cancer Regression in Early Results of Cell Therapy Trial

Just days after a single treatment of a new cell therapy, three glioblastoma patients experienced dramatic reductions in their tumors.
Cell therapy.
News

Targeting Dual Proteins Shows Promise in Reducing Tumor Growth

Targeting two brain tumor-associated proteins—rather than one—with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer.
A row of pipettes filled with red liquid
Article

High-Throughput Screening: Advances, Applications and Combined Approaches

In this article, we highlight various high-throughput screening strategies being used to interrogate large libraries of compounds and hear from researchers working to further streamline specific approaches to increase speed and improve quality and accuracy.
A clinician points at an MRI scan of the brain.
News

Painting a Molecular Portrait of the Brain With Mass Spectrometry and Deep Learning

Mass spectrometry approaches, combined with deep learning, could be used to better understand how the brain functions in health and disease.
Red cancer cells adhered to a grey surface.
Article

Tumor Heterogeneity: Navigating the Next Frontier in Cancer Research

Some types of cancer are still extremely challenging to successfully treat. Once the disease has spread, it is very hard to cure. This article will explore the various types of tumor heterogeneity, how heterogeneity can impact treatment resistance and its influence on precision medicine.
Cancer cells.
News

Enzyme Checkpoint Identified in Tumor-Associated Immune Cells

A study recently published has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.
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