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Spatial Biology – News and Features

Fibroblasts under a microscope.

Understudied Brain Cells May Be Key for Glioblastoma Treatment

Researchers at the University of Notre Dame have found that a largely understudied cell could offer new insight into how the aggressive, primary brain cancer is able to resist immunotherapy.
A xenograft model of prostate cancer. Cells are stained blue, green and red.

Immunotherapy May Have Unexpected Potential for Metastatic Prostate Cancer

Although immunotherapy has proved disappointing in treating prostate cancer, it may have potential when the cancer starts to spread, as metastatic prostate tumors contain more immune cells.
Organoid infographic.

Novel Pancreatic Cancer Organoids Created

Researchers from Japan have created a pancreatic ductal adenocarcinoma (PDAC) organoid model using human-induced pluripotent stem cell (hiPSC) technology, simulating desirable TME properties.
Microfluidic devices

Advances in Organ-on-a-Chip Technology

An organ-on-a-chip is a model system containing engineered cells grown inside microfluidic chips. This article will highlight some recent advances in organ-on-a-chip technology and how they are being used to improve disease modeling and drug discovery.
Human colon cancer cells.

Chemotherapy Becomes Less Effective When Healthy Cells Are Nearby

In two new studies, researchers have used "mini-tumors" to begin to solve the puzzle of why healthy cells in a patient’s bowel cancer tumor might lead to poor outcomes.
A microscope lens pointing at a slide.

New Method Better Maps the Immune Response

A new method has been developed that can identify unique immune cell receptors and their location in tissue, which could improve the ability to identify which immune cells contribute to disease processes.
A plastic model of a pair of lungs, revealing the internal structures.

Lab-Grown Lung Tissue Could Accelerate Lung Disease Drug Discovery

Thin sections of lab-grown lung tissues have revealed new insights into the mechanisms behind lung disease development, potentially accelerating drug discovery.
A neon image of a human outline and brain.

139 Genes Set Human Cognitive Ability Apart From Other Primates

A group of 139 genes commonly expressed in primate brains – which underwent evolutionary divergence only in human brains – may be the source of our unique cognitive abilities according to a study led by the University of Toronto.
A limb showing gene expression patterns.

First Spatial Map of Human Limb Development Reveals Unexpected Insights

Scientists reveal unprecedented insights into human limb development, including the many intricate processes that govern their formation.
Pancreatic cells forming scars around a tumor.

Tumor Growth Protein Strongly Associated With Pancreatic Cancer

Secreted frizzled-related protein 2 – a protein that promotes tumor growth and angiogenesis – has been associated with poor outcomes in pancreatic cancer patients.