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Spatial Biology – News and Features

A strand of RNA.

Exploring the Latest Advances in Transcriptomics

This article explores the latest technologies currently in use for transcriptomic research. It also highlights the latest advancements in transcriptomics technology, focusing on single-cell, spatiotemporal and the “dark-transcriptome”.
A zebrafish.

Atlas of Zebrafish Development Created

Researchers published an atlas of zebrafish development, detailing the gene expression programs that are activated within nearly every cell type during the first five days of development.
Brain cells highlighted in red.

Full Atlas of the Mammalian Brain Reveals Unique Structure of Ancient Regions

A world-first cell atlas has opened a window into the complexity of the mammalian brain. The map details more than 5,000 cell-type clusters in the mouse brain and marks out their location.

Immune Cells Shape Lungs Before Birth

Healthy lung development hinges on immune-epithelial crosstalk, revealing a new role for immune cells outside of immunity, with implications for treating respiratory diseases.
Cancer cells.

Researchers Identify Pathway From Breast Cancer to Brain Metastasis

Moffitt Cancer Center researchers are working to better understand the molecular mechanisms that promote the development and progression of breast cancer brain metastasis to help improve diagnostics and treatments.
A plastic model of one hemisphere of the brain, with a brain cell beside it.

Innovative Method Identifies Rare Brain Cell Types

Researchers have used single-cell sequencing to identify every cell in a system, revealing new brain cell subtypes and enabling detailed research into brain changes in Alzheimer's.
Fibroblasts under a microscope.

Understudied Brain Cells May Be Key for Glioblastoma Treatment

Researchers at the University of Notre Dame have found that a largely understudied cell could offer new insight into how the aggressive, primary brain cancer is able to resist immunotherapy.
A xenograft model of prostate cancer. Cells are stained blue, green and red.

Immunotherapy May Have Unexpected Potential for Metastatic Prostate Cancer

Although immunotherapy has proved disappointing in treating prostate cancer, it may have potential when the cancer starts to spread, as metastatic prostate tumors contain more immune cells.
Organoid infographic.

Novel Pancreatic Cancer Organoids Created

Researchers from Japan have created a pancreatic ductal adenocarcinoma (PDAC) organoid model using human-induced pluripotent stem cell (hiPSC) technology, simulating desirable TME properties.
Microfluidic devices

Advances in Organ-on-a-Chip Technology

An organ-on-a-chip is a model system containing engineered cells grown inside microfluidic chips. This article will highlight some recent advances in organ-on-a-chip technology and how they are being used to improve disease modeling and drug discovery.