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Structural Biology – News and Features

An illustration of sperm cells.

Target for Reversible, Non-Hormonal Male Birth Control Identified in Mice

Researchers from the Salk Institute have uncovered a protein complex that regulates gene expression during sperm production and discovered an oral non-hormonal drug that reversibly stops this process in mice, without obvious side effects.
A water drop splashes as it hits the water's surface.

First-Ever Atomic Freeze-Frame of Liquid Water

Researchers have, for the first time, "frozen" the motion of atoms in liquid water and isolated the energetic movement of electrons.
An alarm clock.

New Epigenetic Clocks Predict Biological Age More Robustly

Investigators unveil a new form of epigenetic clock – a machine learning model designed to predict biological age from DNA structure. The novel model distinguishes between genetic differences that slow and accelerate aging.
The crystal structure of a protein, with the path of an electron mapped out.

How Proteins Act as Electron Navigators

New research has shown how small atomic movements of a protein can guide an electron to its destination, which scientists could mimic in the search for more efficient solar cells.
Vaccine vials.

Vaccine Candidate Shows Promise Against Birth Defect-Causing Virus

An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate.
Male doctor speaking to a male patient.

Clearer Diagnostics, Improved Chances: The Big-Picture Impacts of Improved Cancer Diagnostic Testing

Explore how innovations in the cancer diagnostic space, particularly those focusing on simple but effective diagnostic methodologies, could make cancer screening and early detection more straightforward, improving access and outcomes for patients.
Cell therapy.

Novel Design Improves CAR T-Cell Therapy for Childhood Leukemia

Scientists at St. Jude Children’s Research Hospital improved bispecific chimeric antigen receptor (CAR) T–cell immunotherapies for acute myeloid leukemia (AML), corroborated by computational analysis.
Neuron shapes shown in gold.

A Novel Molecular Mechanism Related to Neuronal Death

New research has revealed a molecular pathway that regulates neural cell death and the transport of mitochondria, which could help identify new therapeutic targets against neurodegenerative disease.
A close up of a leaf.

Efficiently Unlocking Plant Sugars Could Lead to Biofuels and Medicines

Research from Lawrence Berkeley National Laboratory (Berkeley Lab) sheds new light on how to access the sugars locked up in plants to produce petroleum-free fuels, chemicals, and medicines.
Simulated image of an egg and sperm cell at fertilization.

Supercomputer Simulates Protein Complex That Initiates Human Fertilization

Researchers recently developed highly realistic simulations of the proteins on sperm and egg cells coupling together before they fuse. These findings enabled the research team to solve several mysteries of fertilisation at once.