Structural Biology – News and Features

Researchers have created a machine-learning technique for accurately measuring individual particle mass using nanoscale devices. This advancement could revolutionize proteomics by enabling the identification of proteins without fragmenting them.

Researchers have described the full molecular structure of the phage DEV, which uses a genome ejection motor to infect Pseudomonas aeruginosa.

Researchers have developed an advanced technique to analyze protein interactions within cells, revealing that cellular stress significantly alters these interactions. The study demonstrates how this understanding could inform drug development.

A study has unveiled the role of CDK5RAP2 in activating the γ-tubulin ring complex (γTuRC), a vital component for microtubule formation in cells. By using cryo-electron microscopy, the team demonstrated how CDK5RAP2 binds to γTuRC.

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study.

Scientists developed a nanobody, NbE, that binds tightly to opioid receptors, blocking their activity. This could mitigate the severe side effects of opioids and lead to the creation of smaller, more effective molecules.

David Baker, Demis Hassabis and John Jumper have been awarded the 2024 Nobel Prize for Chemistry for their work on computational protein design and protein structure prediction.

This article explores the revolution in new drug modalities and the challenges around effective data strategies to support AI efforts.

One of the largest and most diverse studies to date on genetic factors related to epilepsy has revealed potential new treatment targets.

Researchers at the University of Wisconsin–Madison used cryo-electron tomography to visualize the structure of respiratory syncytial virus (RSV) proteins. Their findings reveal how RSV proteins interact with host cells.