Structural Biology – News and Features

Small-molecule drug (ACBI3) could potentially lead to new therapies independent of KRAS mutation type, improving outcomes for all patients with cancers caused by KRAS mutations.

A team at the University of Missouri has created Cryo2Struct, an AI program that automates the determination of large protein structures from cryo-electron microscopy data. This allows for better understanding of protein interactions.

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also — in a particular subset of T cells — cause mitochondrial stress, DNA damage and cell death.

A new drug molecule could reactivate housekeeping functions in the brain cells of young Parkinson's patients, paving the way for potential future treatments for this incurable, degenerative disease.

A new generative AI model can make it easier to determine the structure of powdered crystals in X-ray crystallography.

A study reveals more than 3,000 genetic changes in a cancer protection gene that heightens breast and ovarian cancer risk. This research enhances risk assessment for patients, especially those with a family history of cancer.

TGF-beta can shake and wiggle within its membrane "straitjacket" to activate neighboring receptors, a new study finds, upending a decades-old dogma on how TGF-beta works.

Researchers have uncovered two new proteins involved in managing the distribution of lipids in cell membranes.

Scientists have uncovered new details about how cells manage the distribution of lipids in their cell membrane. This better understanding of cell membrane regulation could lead to new treatments for diseases, such as epilepsy and anemia.

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a finding that could lead to new strategies to avoid drug resistance.