Vaccine Design and Testing – News and Features

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Paper-Based Devices Diagnose Malaria in Asymptomatic People
Scientists have developed a new paper-based device that can improve the diagnosis of malaria in asymptomatic people. In field tests in Ghana, the device outperformed the current gold standard methods being used in the country's hospitals.

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AI Model Helps Develop a Broad-Spectrum Coronavirus Drug
Multidisciplinary AI- and physics-driven modeling of the viral fusion process has enabled the discovery of an orally available drug inhibiting infection with multiple coronaviruses.

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Protein-Based Nanoparticle Makes mRNA Vaccines More Effective in Chickens
UConn researchers have demonstrated that a novel protein-based nanoparticle can make mRNA vaccines more effective in tackling a troublesome pathogen in chickens.

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Modified mRNA Vaccines Improve T-Cell Response
New research has found that adding IL-12, a cytokine produced by various immune cells, to mRNA vaccines improves T-cell responses. This could make the benefits of vaccines last longer.

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Guillain-Barré Syndrome Risk Linked to COVID-19 and Certain Vaccines
A global study, covering more than 230 million people, sheds light on the relationship between Guillain-Barré syndrome after certain Covid vaccines or SARS-CoV-2 infection.

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Next-Generation mRNA Vaccine Targets Rapidly Evolving Viruses
A new type of mRNA vaccine is more scalable and adaptable to continuously evolving viruses such as SARS-CoV-2 and H5N1, according to a study.

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Researchers Use Machine Learning To Improve Gene Therapy
Scientists have used machine learning to improve the efficacy and safety of targeted cell and gene therapies by potentially using our own proteins. This tool could help to design proteins that avoid unwanted immune responses.

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FDA Grants Limited Approval to Moderna’s Next-Gen COVID-19 Vaccine
Moderna’s next-generation COVID-19 vaccine earns FDA approval for high-risk groups only. Learn what this could mean for future COVID-19 vaccine approvals.

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“Stealthy” Lipid Nanoparticles Avoid the Immune System To Deliver mRNA
A new material developed at Cornell could significantly improve the delivery and effectiveness of mRNA vaccines – used to fight COVID-19 – by replacing a commonly used ingredient that may trigger unwanted immune responses in some people.

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The Original COVID-19 Vaccine Helped Combat Subsequent Variants
Prior COVID-19 vaccination did not stop the immune system from mounting a protective response to the Delta and Omicron strains, though new mutation-specific antibody production dipped slightly, according to a study.
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