We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy


An Overview of Non CYP Mediated Metabolism Pathways and In Vitro Evaluation Strategies

Video   Jun 01, 2021


Presenter: Brian Ogilvie, Ph.D, Vice President of Scientific Consulting at SEKISUI XenoTech


Although cytochrome P450 (CYP)-mediated metabolism continues to be of major importance for a large proportion of small molecule new drug candidates, various methods in recent decades have accelerated the development of drug candidates with significant non CYP-mediated metabolism. Increased interest in these molecules stems from the efforts to develop drug candidates possibly lacking CYP metabolism liability from the drug interactions and toxicity standpoints. Regulatory agencies still have a safety interest in understanding the biochemical pathways involved in the metabolism of these drugs.

In general, uridine diphosphate glucuronosyltransferases (UGTs) are the most common enzymes involved in metabolism after CYP enzymes, followed by numerous hydrolases, carbonyl reductases, aldehyde oxidase and other enzymes. Reaction phenotyping of many of these enzymes is not as straightforward as with CYPs due to their inherent diversity and limited research tools available. With UGTs, commercially available recombinant human preparations are available for the most relevant enzymes, although selective inhibitors may be lacking. In the case of aldehyde oxidase, a recombinant human enzyme and relatively selective inhibitors are available. For hydrolases, carbonyl reductases and other enzymes such as FMO, strategies may rely on the use of various subcellular fractions, plasma, and inhibitors to elucidate a plurality of the enzymes that may contribute to drug metabolism. The complexity of elucidation of non CYP-mediated metabolism is reflected in regulatory safety requirements.

In this webinar, Dr. Brian Ogilvie will discuss strategies to address non-CYP related metabolism questions in your drug’s safety assessment and following the presentation, he will answer follow up questions from the audience.

Key concepts discussed in this webinar will include:

- In vitro approaches to evaluate non-CYP enzyme contribution to new drug candidates

- Case examples

Request a copy of the slides: https://www.xenotech.com/about/events/webinar-an-overview-of-non-cyp-mediated-metabolism-pathways-and-in-vitro-evaluation-strategies/

Questions, comments and requests: https://www.xenotech.com/contact/

More information on our research services and test systems: https://www.xenotech.com

Other previously aired webinars: https://www.xenotech.com/access-adme-research-resources/resource-type/webinar/

Upcoming webinar notifications: https://www.xenotech.com/contact/newsletter-sign-up/

Request a webinar topic: https://www.xenotech.com/contact/webinar-seminar-request/

About the Presenter:

Dr. Brian Ogilvie currently serves as Vice President of Scientific Consulting at SEKISUI XenoTech. Brian obtained his Ph.D. in toxicology from the University of Kansas Medical Center and B.A. in molecular biology from William Jewell College. He joined XenoTech in 1997. From 1999 to 2006 Dr. Ogilvie was the head of the CYP Inhibition Department at SEKISUI XenoTech. Brian is an author or coauthor on over 50 scientific posters, peer-reviewed publications and book chapters on the topics of drug metabolism, transport and drug-drug interactions, and has represented the company as an invited speaker at various drug metabolism conferences. In April 2006, Brian became a member of the SEKISUI XenoTech Consulting Department, in which he participates in drug-drug interaction-related R&D projects and authoring various publications, and also writes expert opinions for consulting clients. As Vice President of Scientific Consulting, Dr. Ogilvie is additionally involved in quality management and strategic planning for the company in scientifically relevant areas.

More Information

Request Information


Recommended Videos

Potential Therapeutic Uses of Cannabinoids With Professor Roger Pertwee


Much of what we know about the cannabis plant and its effects on the human body has only been formally discovered in the past 60 years. A good deal of these pioneering investigations have involved today's Teach Me in 10 guest: Roger Pertwee, an emeritus professor at the University of Aberdeen.


Amersham™ brand ImageQuant™ 800 GxP biomolecular imager – Cytiva


Sensitive, flexible CCD-based imagers designed to support FDA 21 CFR Part 11 EU GMP Annex 11 regulations


Study Identifies Several Existing Drugs As Potential COVID-19 Therapies


Mining the world’s most comprehensive drug repurposing collection for COVID-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that’s driving the ongoing global pandemic.



To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free