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Continuous Biomanufacturing – A New Paradigm for Production of Monoclonal Antibodies

There is growing interest in the development of integrated continuous bioprocesses for the production of important biotherapeutics due to the potential for enhanced productivity, greater flexibility, and improved product quality. The transition from batch to continuous bioprocessing requires a major rethinking of the downstream purification process. This talk will focus on three strategies for continuous bioprocessing: a coupled precipitation-filtration process for initial antibody capture, a countercurrent staged diafiltration system for antibody formulation and High-Performance Countercurrent Membrane Purification for host cell protein removal. These examples highlight how one can adapt membrane systems to continuous bioprocessing, providing exciting opportunities for improved manufacturing of high-value biopharmaceuticals.